Creation and assessment of a software tool for histoanatomical morphometric evaluation of the intestinal wall in pediatric patients with Hirschsprung’s disease - Takeaways - MDSpire

Creation and assessment of a software tool for histoanatomical morphometric evaluation of the intestinal wall in pediatric patients with Hirschsprung’s disease

  • By

  • Tebin Hawez

  • Tobias Erlöv

  • Christina Granéli

  • Gustav Andersson

  • Tyra Lundberg

  • Emma Fransson

  • Maria Evertsson

  • Magnus Cinthio

  • Pernilla Stenström

  • March 21, 2026

  • 0 min

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  • 1

    A computer program was developed to perform high-precision histoanatomical morphometric measurements of bowel wall in pediatric Hirschsprung’s disease.

  • 2

    The program aims to reduce observer bias and variability while providing efficient and reproducible measurements of bowel wall layers.

  • 3

    Validation of the program included inter-observer and intra-observer reliability analyses, comparing results with manual measurements.

  • 4

    Histopathological images were sourced from patients with rectosigmoid Hirschsprung’s disease, ensuring a homogeneous patient group for the study.

  • 5

    The software features a user-friendly interface and semi-automatic methods for accurate delineation and calculation of bowel wall layer thicknesses.

Original Source(s)

Creation and assessment of a software tool for histoanatomical morphometric evaluation of the intestinal wall in pediatric patients with Hirschsprung’s disease

  • by Tebin Hawez, Tobias Erlöv, Christina Granéli, Gustav Andersson, Tyra Lundberg, Emma Fransson, Maria Evertsson, Magnus Cinthio, Pernilla Stenström

  • March 21, 2026

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