Dosimetric and clinical outcomes of stereotactic body radiotherapy for primary lung cancer: isocenter-based vs. volume-based prescription

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Stereotactic body radiotherapy (SBRT) is the standard treatment for medically inoperable early-stage non-small cell lung cancer (NSCLC).
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Volume-based dose prescriptions in SBRT provide superior dosimetric outcomes compared to traditional isocenter-based prescriptions.
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Patients receiving volume-based prescriptions showed significantly higher three-year overall survival and local control rates than those with isocenter-based prescriptions.
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Volume-based planning reduced lung radiation exposure, evidenced by lower mean lung doses and reduced irradiated lung volumes.
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The incidence of Grade 2–5 radiation pneumonitis was similar between both prescription methods, indicating comparable pulmonary toxicity.

Frontiers In Medicine

by Mitsuru Okubo, Tomohiro Itonaga, Tatsuhiko Zama, Ryuji Mikami, Yukinori Okada, Tsubasa Kawamoto, Shiho Wada, Shinji Sugahara, Kazuhiro Saito
May 18, 2026

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