Advancing Understanding of Secondary Lymphedema Pathophysiology Through Omics Approaches

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Secondary lymphedema can occur due to disruption of lymphatic vasculature from infection, surgery, or cancer treatment.
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Omics technologies provide insights into inflammatory, fibrotic, metabolic, and genetic factors influencing secondary lymphedema.
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Studies using transcriptomic and proteomic approaches have identified candidate biomarkers and therapeutic targets for secondary lymphedema.
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Current limitations in omics research include issues with sample types, bioinformatic pipelines, and methodological approaches.
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Future multi-omics strategies are proposed to enhance diagnosis, risk stratification, and treatment development for secondary lymphedema.

Frontiers In Immunology

by Annica R. Stull-Lane, Xizhao Chen, Abraham J. Book, Radomir Kratchmarov, Sarit Pal, Jinyeon Shin, Gopika Ashokan, Geoffrey E. Hespe, Babak J. Mehrara, Raghu P. Kataru
July 20, 2026

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