Clinicopathological landscape and management trends of thyroid carcinoma over two decades: a single-institution study and risk stratification of central lymph node metastasis in T1 papillary thyroid carcinoma - Takeaways - MDSpire

Clinicopathological landscape and management trends of thyroid carcinoma over two decades: a single-institution study and risk stratification of central lymph node metastasis in T1 papillary thyroid carcinoma

  • By

  • Li’nan Qin

  • Xindi Ke

  • Yongdu Nie

  • Yiming Zhu

  • Shaoyan Liu

  • Jian Wang

  • April 30, 2026

  • 0 min

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  • 1

    The study analyzed 34,420 patients to describe the evolving clinicopathological landscape of thyroid carcinoma from 1999 to 2018.

  • 2

    The proportion of thyroid cancer diagnoses increased to 99.3% by 2018, with papillary thyroid carcinoma accounting for the majority.

  • 3

    Central lymph node dissection rates rose significantly from 34.4% to 97%, while the rate of central lymph node metastasis decreased from 81.8% to 55%.

  • 4

    Independent risk factors for central lymph node metastasis in T1-stage papillary thyroid carcinoma included younger age, male sex, and larger tumor diameter.

  • 5

    A nomogram was developed to predict central lymph node metastasis, showing good discrimination and potential for individualized patient management.

Original Source(s)

Clinicopathological landscape and management trends of thyroid carcinoma over two decades: a single-institution study and risk stratification of central lymph node metastasis in T1 papillary thyroid carcinoma

  • by Li’nan Qin, Xindi Ke, Yongdu Nie, Yiming Zhu, Shaoyan Liu, Jian Wang

  • April 30, 2026

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