Analysis of immune and autophagy-related genes and their regulatory mechanisms in osteoporosis patients post-menopause - Takeaways - MDSpire

Analysis of immune and autophagy-related genes and their regulatory mechanisms in osteoporosis patients post-menopause

  • By

  • Zhanfeng Zhang

  • Jianyou Li

  • Kuan Ni

  • Chengyin Lei

  • Xining Li

  • Yunliang Yao

  • June 1, 2026

  • 0 min

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  • 1

    Postmenopausal osteoporosis (PMO) is a metabolic bone disease linked to immune dysregulation and autophagy.

  • 2

    Three hub genes, CDK2, DDIT3, and MAPK8, were identified as key players in PMO through bioinformatics analysis.

  • 3

    A diagnostic model based on these hub genes demonstrated high predictive accuracy with an AUC of 0.91.

  • 4

    Functional enrichment analysis revealed that CDK2 and DDIT3 are associated with ligand-receptor interaction pathways.

  • 5

    In vivo studies using an ovariectomized mouse model showed significant changes in bone density and hub gene expression.

Original Source(s)

Analysis of immune and autophagy-related genes and their regulatory mechanisms in osteoporosis patients post-menopause

  • by Zhanfeng Zhang, Jianyou Li, Kuan Ni, Chengyin Lei, Xining Li, Yunliang Yao

  • June 1, 2026

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