Unexpected Resolution of Stage IV Diffuse Large B-Cell Lymphoma in an HIV-Positive Patient: A Case Study and Review of Existing Literature - Takeaways - MDSpire

Unexpected Resolution of Stage IV Diffuse Large B-Cell Lymphoma in an HIV-Positive Patient: A Case Study and Review of Existing Literature

  • By

  • Wei Zhang

  • Changgang Deng

  • Qisui Li

  • Jing Yuan

  • April 29, 2026

  • 0 min

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  • 1

    A 66-year-old male with stage IV DLBCL and HIV achieved complete tumor resolution after starting cART, without cytotoxic therapy.

  • 2

    The patient maintained remission for over 36 months, correlating with effective viral suppression and CD4+ T-cell recovery.

  • 3

    Spontaneous regression of stage IV DLBCL is extremely rare in HIV-positive patients, highlighting a unique case.

  • 4

    The case emphasizes the importance of early cART initiation in HIV-positive lymphoma patients to restore immune function.

  • 5

    HIV-associated DLBCL remains a significant health challenge, with poor outcomes despite treatment, particularly in advanced stages.

Original Source(s)

Unexpected Resolution of Stage IV Diffuse Large B-Cell Lymphoma in an HIV-Positive Patient: A Case Study and Review of Existing Literature

  • by Wei Zhang, Changgang Deng, Qisui Li, Jing Yuan

  • April 29, 2026

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