Serial Bias Differs in Schizophrenia vs Bipolar Disorder

Findings suggest a schizophrenia-like subgroup within bipolar disorder, with implications for targeted treatment approaches

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Patients with schizophrenia exhibited a repulsive serial bias in working memory, contrasting with bipolar disorder patients who showed a mixed pattern.
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Healthy controls demonstrated an attractive bias, while patients with bipolar disorder had a weaker attractive bias compared to controls.
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Working memory precision was lower in schizophrenia patients than in bipolar disorder patients and healthy controls, indicating faster memory decline.
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The study suggests that serial bias could serve as a biomarker for treatment development, focusing on biologically defined subgroups.
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Findings indicate potential neurobiological overlap between some bipolar disorder patients and schizophrenia, challenging traditional diagnostic boundaries.

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