Multifocal Noninvasive Deep Brain Stimulation to Enhance Cognition in Mild Cognitive Impairment: A Crossover - Takeaways - MDSpire

Multifocal Noninvasive Deep Brain Stimulation to Enhance Cognition in Mild Cognitive Impairment: A Crossover

  • By

  • Umberto Nencha

  • Monika Pupíková

  • Margaux di Natale

  • Pablo Maceira-Elvira

  • Martin Gajdoš

  • Elena Beanato

  • Stavriani Skarvelaki

  • Rebecca Jones

  • Isabel Ericson

  • Martin Lamoš

  • Andrea Nuti

  • Fabienne Windel

  • David Ondráček

  • Adam Šimo

  • Ela Vojtková

  • Klára Špunarová

  • Vincent Alvarez

  • Oana Simionescu

  • Giovanni B. Frisoni

  • Estelle Raffin

  • Irena Rektorová

  • Friedhelm C. Hummel

  • July 6, 2026

  • 0 min

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  • 1

    Working memory (WM) is often impaired in mild cognitive impairment (MCI), affecting daily functioning and autonomy.

  • 2

    The study investigates noninvasive dual-target neuromodulation of the striatum and cerebellum to enhance WM in MCI patients.

  • 3

    Cerebellar transcranial magnetic stimulation (TMS) and striatal transcranial temporal interference stimulation (tTIS) were applied in the trial.

  • 4

    The trial enrolled patients with amnestic MCI and MCI with Lewy bodies, along with age-matched healthy controls.

  • 5

    Neuropsychological testing revealed that patients with aMCI were more impaired than both healthy controls and MCI-LB patients.

Original Source(s)

Multifocal Noninvasive Deep Brain Stimulation to Enhance Cognition in Mild Cognitive Impairment: A Crossover

  • by Umberto Nencha, Monika Pupíková, Margaux di Natale, Pablo Maceira-Elvira, Martin Gajdoš, Elena Beanato, Stavriani Skarvelaki, Rebecca Jones, Isabel Ericson, Martin Lamoš, Andrea Nuti, Fabienne Windel, David Ondráček, Adam Šimo, Ela Vojtková, Klára Špunarová, Vincent Alvarez, Oana Simionescu, Giovanni B. Frisoni, Estelle Raffin, Irena Rektorová, Friedhelm C. Hummel

  • July 6, 2026

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