Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis - Takeaways - MDSpire

Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis

  • By

  • Xinping Cui

  • Rong Feng

  • Bin Song

  • Qian Zhou

  • Yan Zeng

  • May 21, 2026

  • 0 min

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  • 1

    The meta-analysis assessed the association between maternal NSAID use during pregnancy and kidney disease risk in children.

  • 2

    Seven studies with 4,159,617 participants indicated a significant association between prenatal NSAIDs exposure and kidney disease (OR 1.36).

  • 3

    Adjusted analyses showed a stronger association, with an odds ratio of 2.40 for kidney disease risk linked to NSAID use during pregnancy.

  • 4

    NSAID use in the second and third trimesters was specifically associated with increased kidney disease risk in children.

  • 5

    The study concludes that while an association exists, further high-quality research is needed to clarify causality regarding NSAID use and kidney disease.

Original Source(s)

Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis

  • by Xinping Cui, Rong Feng, Bin Song, Qian Zhou, Yan Zeng

  • May 21, 2026

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