Evaluation of Extravascular Lung Water Index in ARDS Patients Undergoing Veno-Venous ECMO: A Comparison of Transpulmonary Thermodilution and AI-Based Chest CT Analysis

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The study evaluates the extravascular lung water index (EVLWI) in ARDS patients on veno-venous ECMO using transpulmonary thermodilution and AI-based CT analysis.
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Transpulmonary thermodilution (TPTD) may overestimate EVLWI in ECMO patients due to the confounding effects of extracorporeal blood flow.
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AI-based automated lung segmentation allows for rapid and reproducible quantification of EVLW from chest CT scans, independent of ECMO-related hemodynamic interference.
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The study aims to compare EVLWI values from AI-based CT analysis with those from TPTD and derive a correction factor for TPTD in ECMO patients.
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Chest CT is underutilized for EVLWI assessment in ARDS due to manual segmentation challenges, which AI advancements can help overcome.

Bmc Pulmonary Medicine

by Matthias Otto, David Mohr, Julia Zimmermann, Nils Rathmann, Christoph Boesing, Manfred Thiel, Joerg Krebs, Thomas Luecke, Patricia R.M. Rocco, Alice Marguerite Conrad
April 7, 2026

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