Sponge-like sonographic pattern of the spleen in immune dysregulation disorders - Takeaways - MDSpire

Sponge-like sonographic pattern of the spleen in immune dysregulation disorders

  • By

  • Giorgio Costagliola

  • Emanuela De Marco

  • Leonardo Amato

  • Giulia Roberti

  • Elena Sabattini

  • Fabrizio Catena

  • Mattia Moratti

  • Gabriella Casazza

  • Francesca Conti

  • Rita Consolini

  • June 15, 2026

  • 0 min

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  • 1

    A newly described 'sponge-like' splenic microtexture pattern was identified in patients with inborn errors of immunity (IEIs) and immune dysregulation.

  • 2

    In a cohort of 26 patients with IEIs, 30.8% exhibited a persistent sponge-like pattern on splenic ultrasound, despite the absence of infections or malignancies.

  • 3

    The index case, an 11-year-old boy, showed a sponge-like pattern characterized by multiple hypoechoic round foci detected by high-frequency ultrasound.

  • 4

    Immunomodulation treatments, including sirolimus and rituximab, resulted in significant improvement or normalization of the sponge-like splenic pattern.

  • 5

    The findings suggest that identifying the sponge-like pattern may support earlier suspicion of underlying IEIs in patients with immune dysregulation.

Original Source(s)

Sponge-like sonographic pattern of the spleen in immune dysregulation disorders

  • by Giorgio Costagliola, Emanuela De Marco, Leonardo Amato, Giulia Roberti, Elena Sabattini, Fabrizio Catena, Mattia Moratti, Gabriella Casazza, Francesca Conti, Rita Consolini

  • June 15, 2026

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