Single-cell and spatial profiling reveal an IL-10–associated iCAF–M2 macrophage communication axis in high-grade serous ovarian cancer ascites - Takeaways - MDSpire

Single-cell and spatial profiling reveal an IL-10–associated iCAF–M2 macrophage communication axis in high-grade serous ovarian cancer ascites

  • By

  • Ren Li

  • Jinquan Xia

  • Chang Zou

  • Yixia Xie

  • Yuan Shen

  • July 10, 2026

  • 0 min

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  • 1

    High-grade serous ovarian cancer (HGSOC) ascites is characterized by immunosuppressive tumor microenvironments and complex stromal-immune interactions.

  • 2

    Single-cell RNA sequencing revealed macrophages and cancer-associated fibroblasts as dominant populations in HGSOC ascites.

  • 3

    IL-10–IL-10RA signaling was identified as a key communication pathway linking inflammatory CAFs with M2-like macrophages.

  • 4

    Multiplex immunofluorescence confirmed spatial interactions between IL-10+ iCAFs and IL-10RA+ M2 macrophages in tumor tissues.

  • 5

    IL-10 blockade with MK-1966 in immune-humanized PDX models significantly suppressed tumor growth and reduced M2 macrophage markers.

Original Source(s)

Single-cell and spatial profiling reveal an IL-10–associated iCAF–M2 macrophage communication axis in high-grade serous ovarian cancer ascites

  • by Ren Li, Jinquan Xia, Chang Zou, Yixia Xie, Yuan Shen

  • July 10, 2026

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