White matter changes in Alzheimer's disease: contributor, consequence or co-pathology?

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Alzheimer's disease is increasingly recognized for significant white matter changes alongside traditional grey matter pathology.
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White matter alterations may either be an independent co-pathology or a central event in Alzheimer's disease progression.
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Cortical tau deposition is linked to lower white matter volume and accelerated white matter loss over time.
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The study suggests tau aggregation precedes white matter degeneration, challenging the view of white matter as merely co-pathological.
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Methodological limitations exist, highlighting the need for further studies to clarify the relationship between tau and white matter changes.

Brain

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