Non-linear association between thyroid scintigraphy-derived thyroid weight and I-131 treatment efficacy in graves’ disease: a multicenter restricted cubic spline and threshold analysis - Takeaways - MDSpire

Non-linear association between thyroid scintigraphy-derived thyroid weight and I-131 treatment efficacy in graves’ disease: a multicenter restricted cubic spline and threshold analysis

  • By

  • Lu Lu

  • LeLe Zhang

  • Dongyun Meng

  • Xiaojuan Wei

  • Yan Chen

  • Shaozhou Mo

  • Zeyong Sun

  • Fengyang Song

  • Yuehua Li

  • Xingyu Mu

  • Wentan Huang

  • Wei Fu

  • Kehua Liao

  • July 17, 2026

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  • 1

    This study analyzed 612 patients with Graves' disease who received I-131 treatment between 2018 and 2024.

  • 2

    A significant non-linear relationship was found between thyroid weight and I-131 treatment efficacy, with an exploratory inflection point at 46 g.

  • 3

    40.8% of patients experienced non-remission after initial I-131 therapy, highlighting variability in treatment outcomes.

  • 4

    Independent predictors of non-remission included thyroid weight, female gender, and disease duration greater than two years.

  • 5

    The findings support the need for individualized RAI dosing strategies based on thyroid weight thresholds.

Original Source(s)

Non-linear association between thyroid scintigraphy-derived thyroid weight and I-131 treatment efficacy in graves’ disease: a multicenter restricted cubic spline and threshold analysis

  • by Lu Lu, LeLe Zhang, Dongyun Meng, Xiaojuan Wei, Yan Chen, Shaozhou Mo, Zeyong Sun, Fengyang Song, Yuehua Li, Xingyu Mu, Wentan Huang, Wei Fu, Kehua Liao

  • July 17, 2026

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