Bone in Parathyroid Diseases Revisited: Evidence From Epidemiological, Surgical and New Drug Outcomes

1

Parathyroid disorders significantly affect bone metabolism, leading to various skeletal abnormalities due to altered calcium and phosphate homeostasis.
2

Hyperparathyroidism results in increased bone turnover and resorption, often leading to decreased bone mineral density and fragility fractures.
3

Successful parathyroidectomy can reverse skeletal defects in hyperparathyroidism, while calcimimetics and antiresorptive agents serve as alternatives.
4

Hypoparathyroidism causes low bone turnover and increased bone mineral density, but can lead to compromised bone strength and higher fracture risk.
5

Recombinant human PTH is effective for hypoparathyroidism but is reserved for refractory cases, with calcium and vitamin D as first-line treatments.

Endocrine Reviews

by Afroditi Roumpou, Andrea Palermo, Symeon Tournis, Valeria Hasenmajer, Janice L Pasieka, Gregory Kaltsas, Andrea Isidori, Eva Kassi
April 3, 2025

1