Distinct medication-state modulation of motor-cortical low-beta power in tremor-dominant and postural instability/gait difficulty Parkinson’s disease: a source-space resting-state EEG study - Takeaways - MDSpire

Distinct medication-state modulation of motor-cortical low-beta power in tremor-dominant and postural instability/gait difficulty Parkinson’s disease: a source-space resting-state EEG study

  • By

  • Hao Wang

  • Xiangyu Chen

  • Guoqing Wu

  • Xiaowei Du

  • Ganqin Du

  • June 25, 2026

  • 0 min

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  • 1

    The study examined motor-cortical low-beta activity in tremor-dominant and postural instability/gait difficulty subtypes of Parkinson's disease using resting-state EEG.

  • 2

    Participants included 20 patients with postural instability/gait difficulty, 18 with tremor-dominant, and 12 healthy controls, assessed in medication OFF and ON states.

  • 3

    Low-beta power increased significantly in the PIGD group from OFF to ON, while the TD group showed minimal change, indicating distinct medication-state modulation.

  • 4

    The primary weighted phase lag index endpoint was not significant, but exploratory analyses revealed differences in high-beta connectivity between subtypes.

  • 5

    The findings suggest that motor-cortical low-beta power is a consistent electrophysiological difference between tremor-dominant and PIGD subtypes.

Original Source(s)

Distinct medication-state modulation of motor-cortical low-beta power in tremor-dominant and postural instability/gait difficulty Parkinson’s disease: a source-space resting-state EEG study

  • by Hao Wang, Xiangyu Chen, Guoqing Wu, Xiaowei Du, Ganqin Du

  • June 25, 2026

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