Postoperative radiotherapy for resected esophageal squamous cell carcinoma: a systematic review and meta-analysis - Takeaways - MDSpire

Postoperative radiotherapy for resected esophageal squamous cell carcinoma: a systematic review and meta-analysis

  • By

  • Ning Zhou

  • Peipei Zhao

  • Miaomiao Zhao

  • Fen Wen

  • Wei Geng

  • Zhenhua Liu

  • July 14, 2026

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  • 1

    Postoperative radiotherapy (PORT) significantly improves overall survival (OS) and disease-free survival (DFS) in patients with resected esophageal squamous cell carcinoma (ESCC).

  • 2

    PORT reduces locoregional recurrence (LRR) but does not affect distant metastasis (DM) in patients with radically resected ESCC.

  • 3

    Subgroup analyses indicate that PORT enhances OS in patients with positive lymph nodes, T3-4 stage, and those receiving modern radiotherapy techniques.

  • 4

    The addition of chemotherapy to PORT provides the greatest overall survival benefit in patients with resected ESCC.

  • 5

    PORT is associated with a higher incidence of grade ≥3 acute toxicity, primarily radiation esophagitis and leukopenia, though grade ≥4 toxicity is rare.

Original Source(s)

Postoperative radiotherapy for resected esophageal squamous cell carcinoma: a systematic review and meta-analysis

  • by Ning Zhou, Peipei Zhao, Miaomiao Zhao, Fen Wen, Wei Geng, Zhenhua Liu

  • July 14, 2026

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