Childhood-onset systemic lupus erythematosus presenting with growth retardation and delayed puberty: a case report - Takeaways - MDSpire

Childhood-onset systemic lupus erythematosus presenting with growth retardation and delayed puberty: a case report

  • By

  • Yumo Liu

  • Xinyu Li

  • Zhengnan Gao

  • Xuhan Liu

  • May 25, 2026

  • 0 min

Share

  • 1

    Childhood-onset systemic lupus erythematosus (cSLE) can present atypically with growth retardation and delayed puberty, complicating diagnosis.

  • 2

    A 12-year-old girl exhibited progressive growth delays and absence of pubertal development, leading to further evaluation for cSLE.

  • 3

    Diagnosis of cSLE was confirmed through findings of proteinuria, hypoalbuminemia, and immunological abnormalities.

  • 4

    Despite immunosuppressive therapy improving systemic manifestations, growth and pubertal progression remained impaired.

  • 5

    Early recognition of cSLE is crucial in adolescents with unexplained growth or pubertal delays, especially with renal or immunological signs.

Original Source(s)

Childhood-onset systemic lupus erythematosus presenting with growth retardation and delayed puberty: a case report

  • by Yumo Liu, Xinyu Li, Zhengnan Gao, Xuhan Liu

  • May 25, 2026

Related Content

Plasmacytoid dendritic cells in systemic and cutaneous lupus erythematosus: an evolving understanding

A dynamic vascular–inflammatory–fibrotic loop in systemic sclerosis: an integrative immuno-vascular framework

Comparative effectiveness and safety of biologics and targeted small-molecule therapies plus stable background therapy in systemic lupus erythematosus: a systematic review and network meta-analysis