Quantitative dynamic contrast-enhanced magnetic resonance imaging for early assessment of treatment response in pancreatic ductal adenocarcinoma - Takeaways - MDSpire
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Dynamic contrast-enhanced MRI for early evaluation of therapeutic response in pancreatic ductal adenocarcinoma

  • By

  • Martin D. Holland

  • Ezinwanne E. Onuoha

  • Darryl Outlaw

  • Mehmet Akce

  • Midhun Malla

  • Salila Hashmi

  • Sushanth Reddy

  • J. Bart Rose

  • Desiree E. Morgan

  • Grant R. Williams

  • Moh’d Khushman

  • Dana B. Cardin

  • Katherine Frederick-Dyer

  • Xiaoyu Jiang

  • Zarine K. Shah

  • Bassel El-Rayes

  • Junzhong Xu

  • Harrison Kim

  • August 22, 2026

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  • 1

    Pancreatic ductal adenocarcinoma (PDAC) has a low five-year survival rate of approximately 10% due to late diagnosis and limited treatment options.

  • 2

    Dynamic contrast-enhanced MRI (DCE-MRI) may provide early evaluation of PDAC response to chemotherapy by quantifying tissue perfusion.

  • 3

    A portable perfusion phantom (P4) was developed to correct inter- and intra-scanner variability in DCE-MRI measurements.

  • 4

    In a preliminary study, P4-corrected DCE-MRI measurements differentiated responders from non-responders better than RECIST.

  • 5

    The study aimed to validate the clinical utility of quantitative DCE-MRI for predicting early treatment response in PDAC at two institutions.

Original Source(s)

Quantitative dynamic contrast-enhanced magnetic resonance imaging for early assessment of treatment response in pancreatic ductal adenocarcinoma

  • by Martin D. Holland, Ezinwanne E. Onuoha, Darryl Outlaw, Mehmet Akce, Midhun Malla, Salila Hashmi, Sushanth Reddy, J. Bart Rose, Desiree E. Morgan, Grant R. Williams, Moh’d Khushman, Dana B. Cardin, Katherine Frederick-Dyer, Xiaoyu Jiang, Zarine K. Shah, Bassel El-Rayes, Junzhong Xu, Harrison Kim

  • August 22, 2026

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