Changes in circulating immune cells and cytokines after high-intensity aerobic exercise in patients with prostate cancer undergoing active surveillance from the ERASE randomized controlled trial - Takeaways - MDSpire
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Impact of High-Intensity Aerobic Exercise on Immune Cell Dynamics and Cytokine Levels in Prostate Cancer Patients Undergoing Active Surveillance: Insights from the ERASE Randomized Controlled Trial

  • By

  • Dong-Woo Kang

  • Dhruvesh Patel

  • Catherine J. Field

  • Normand G. Boulé

  • Adrian S. Fairey

  • Keri L. Schadler

  • Kerry S. Courneya

  • September 7, 2026

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  • 1

    The ERASE trial evaluated the effects of high-intensity interval training (HIIT) on immune cell dynamics in prostate cancer patients under active surveillance.

  • 2

    Fifty-two men with localized prostate cancer were randomized into HIIT or usual care, with HIIT consisting of three sessions weekly for 12 weeks.

  • 3

    HIIT significantly increased the proportion of the NK-cell subset and PBMC-mediated cytotoxicity compared to usual care.

  • 4

    Plasma levels of IL-4 and IL-12p70 were significantly reduced in the HIIT group, while other leukocyte populations showed no significant differences.

  • 5

    The study's findings are exploratory and require confirmation in larger studies due to the design and multiple comparisons involved.

Original Source(s)

Changes in circulating immune cells and cytokines after high-intensity aerobic exercise in patients with prostate cancer undergoing active surveillance from the ERASE randomized controlled trial

  • by Dong-Woo Kang, Dhruvesh Patel, Catherine J. Field, Normand G. Boulé, Adrian S. Fairey, Keri L. Schadler, Kerry S. Courneya

  • September 7, 2026

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