Shared genetic associations and aetiology between obstructive sleep apnoea and cardiovascular diseases: a genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis - Takeaways - MDSpire

Shared genetic associations and aetiology between obstructive sleep apnoea and cardiovascular diseases: a genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis

  • By

  • Kun Feng

  • Jinyue Yang

  • Kai Liu

  • November 5, 2024

  • 0 min

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  • 1

    The study identifies strong genetic correlations between obstructive sleep apnoea (OSA) and several cardiovascular diseases (CVDs).

  • 2

    Novel single-nucleotide polymorphisms related to cardiovascular diseases were discovered through single-trait multi-trait analysis of GWAS.

  • 3

    Atrial fibrillation was found to be a causal factor for OSA, while OSA was identified as a causal factor for heart failure.

  • 4

    Fifteen shared loci between OSA and coronary artery disease, and 25 shared loci between OSA and myocardial infarction were identified.

  • 5

    Further research is necessary to explore the genetic mechanisms linking OSA and CVDs to improve recognition and treatment.

Original Source(s)

Shared genetic associations and aetiology between obstructive sleep apnoea and cardiovascular diseases: a genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis

  • by Kun Feng, Jinyue Yang, Kai Liu

  • November 5, 2024

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