1-L Prep Boosts Quality, Not Adequacy - Takeaways - MDSpire

1-L Prep Boosts Quality, Not Adequacy

Randomized trial in hospitalized patients found improved high-quality bowel cleansing with 1-L regimen, though primary endpoint differences were not statistically significant

  • By

  • Andrea Surnit

  • May 5, 2026

  • 3 min

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  • 1

    A 1-L polyethylene glycol-ascorbate bowel preparation resulted in higher rates of high-quality colon cleansing compared to 2-L and 4-L regimens.

  • 2

    Adequate cleansing rates were similar across all groups, with 82% for 1 L, 78% for 2 L, and 79% for 4 L, indicating no significant differences.

  • 3

    High-quality cleansing occurred in 47% of patients receiving 1 L, compared to 35% with 2 L and 37% with 4 L, showing a notable improvement.

  • 4

    Willingness to repeat the bowel preparation was highest in the 1-L group at 84%, suggesting better patient satisfaction with this regimen.

  • 5

    The trial's findings are applicable to clinically stable hospitalized patients and may not generalize to those with urgent or severe conditions.

Original Source(s)

1-L Prep Boosts Quality, Not Adequacy

  • by Andrea Surnit

  • May 5, 2026

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