Bulk and single-cell RNA sequencing data identified HMGB3 of chromatin regulators as a breast cancer biomarker associated with the cell cycle - Takeaways - MDSpire

Bulk and single-cell RNA sequencing data identified HMGB3 of chromatin regulators as a breast cancer biomarker associated with the cell cycle

  • By

  • Huan Wang

  • Luhui Li

  • Dingyuan Tu

  • Ping Shen

  • Zheyao Song

  • Mengjiao An

  • Xudong Li

  • Qi Ji

  • Peng Chen

  • Rongjun Cui

  • June 11, 2026

  • 0 min

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  • 1

    The study identified eleven chromatin regulators (CRs) associated with breast cancer (BRCA) through transcriptome and single-cell RNA sequencing.

  • 2

    A prognostic model was developed using median risk scores to categorize BRCA patients into high- and low-risk groups.

  • 3

    Low-risk BRCA patients exhibited significantly higher immune cell infiltration compared to high-risk patients.

  • 4

    Immunohistochemistry confirmed that HMGB3 expression levels are closely linked to BRCA.

  • 5

    In vitro assays demonstrated that HMGB3 promotes BRCA cell invasion and malignant progression via cell cycle regulation.

Original Source(s)

Bulk and single-cell RNA sequencing data identified HMGB3 of chromatin regulators as a breast cancer biomarker associated with the cell cycle

  • by Huan Wang, Luhui Li, Dingyuan Tu, Ping Shen, Zheyao Song, Mengjiao An, Xudong Li, Qi Ji, Peng Chen, Rongjun Cui

  • June 11, 2026

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