BAFF and APRIL signaling in the B-cell lineage: implications for the pathogenesis of ANCA-associated vasculitis - Takeaways - MDSpire

Signaling Pathways of BAFF and APRIL in B-Cell Development: Relevance to ANCA-Associated Vasculitis Pathogenesis

  • By

  • Yasuhiro Shimojima

  • Shuhei Yoshida

  • Haruki Matsumoto

  • Yuya Sumichika

  • Tomoyuki Asano

  • Shuzo Sato

  • July 21, 2026

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  • 1

    B-lineage cells are crucial in ANCA-associated vasculitis (AAV) by producing ANCA and secreting proinflammatory cytokines.

  • 2

    Elevated BAFF and APRIL levels contribute to autoreactive B cell activation and survival, leading to AAV onset and relapse.

  • 3

    Active AAV is characterized by expansions of specific B-cell phenotypes, including plasmablasts and plasma cells.

  • 4

    B-cell depletion therapy with rituximab is effective but requires repeated administration to maintain remission.

  • 5

    Targeting BAFF/APRIL signaling pathways is essential for developing novel therapeutic strategies for AAV.

Original Source(s)

BAFF and APRIL signaling in the B-cell lineage: implications for the pathogenesis of ANCA-associated vasculitis

  • by Yasuhiro Shimojima, Shuhei Yoshida, Haruki Matsumoto, Yuya Sumichika, Tomoyuki Asano, Shuzo Sato

  • July 21, 2026

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