Effects of Intranasal Naloxone on Hypoglycemia-associated Autonomic Failure in Susceptible Individuals - Takeaways - MDSpire

Effects of Intranasal Naloxone on Hypoglycemia-associated Autonomic Failure in Susceptible Individuals

  • By

  • Sandra Aleksic

  • Eric Lontchi-Yimagou

  • William Mitchell

  • Caroline Boyle

  • Priyanka Matias

  • Anjali Manavalan

  • Akankasha Goyal

  • Michelle Carey

  • Ilan Gabriely

  • Meredith Hawkins

  • July 19, 2024

  • 0 min

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  • 1

    Hypoglycemia-associated autonomic failure (HAAF) blunts counterregulatory responses in diabetes, complicating treatment and increasing risks.

  • 2

    Intranasal naloxone may ameliorate HAAF by maintaining hormonal and symptomatic responses during hypoglycemia.

  • 3

    In a study of 17 participants, 9 developed HAAF, highlighting individual variability in susceptibility to this condition.

  • 4

    Naloxone reduced plasma epinephrine and GH responses during the first hypoglycemic episode but prevented further reductions.

  • 5

    This study is the first to suggest that intranasal naloxone could be a feasible outpatient strategy for managing HAAF.

Original Source(s)

Effects of Intranasal Naloxone on Hypoglycemia-associated Autonomic Failure in Susceptible Individuals

  • by Sandra Aleksic, Eric Lontchi-Yimagou, William Mitchell, Caroline Boyle, Priyanka Matias, Anjali Manavalan, Akankasha Goyal, Michelle Carey, Ilan Gabriely, Meredith Hawkins

  • July 19, 2024

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