Hoxb4 upregulation by Xuan Bi Tong Yu Fang confers cardioprotection via repression of the Wnt/β-catenin pathway in myocardial ischemia-reperfusion injury - Takeaways - MDSpire

Hoxb4 upregulation by Xuan Bi Tong Yu Fang confers cardioprotection via repression of the Wnt/β-catenin pathway in myocardial ischemia-reperfusion injury

  • By

  • Peng-fei Li

  • Han-ying Xu

  • Tian-ying Liu

  • Xiao-hui Li

  • Hong-yu Li

  • Guang-yu Cheng

  • Ai-dong Liu

  • Shuang-di Li

  • May 7, 2026

  • 0 min

Share

  • 1

    Xuan Bi Tong Yu Fang (XBTYF) provides cardioprotection in myocardial ischemia-reperfusion injury by upregulating Hoxb4 and inhibiting the Wnt/β-catenin pathway.

  • 2

    In a study with Wistar rats, XBTYF significantly reduced myocardial enzyme levels and infarct size compared to control groups.

  • 3

    RNA sequencing identified Hoxb4 as a key gene restored by XBTYF, which also inhibited the Wnt/β-catenin signaling pathway.

  • 4

    In vitro experiments showed that XBTYF treatment increased Hoxb4 levels, promoting cardiomyocyte proliferation and reducing apoptosis.

  • 5

    The findings support XBTYF as a potential adjunctive therapy for myocardial ischemia-reperfusion injury, warranting further clinical research.

Original Source(s)

Hoxb4 upregulation by Xuan Bi Tong Yu Fang confers cardioprotection via repression of the Wnt/β-catenin pathway in myocardial ischemia-reperfusion injury

  • by Peng-fei Li, Han-ying Xu, Tian-ying Liu, Xiao-hui Li, Hong-yu Li, Guang-yu Cheng, Ai-dong Liu, Shuang-di Li

  • May 7, 2026

Related Content

Functional consequences of diminished myocardial oxygen delivery per beat in experimental heart failure

Retatrutide Shows 28% Weight Loss in Phase 3 Trial

Nearly half of participants receiving the highest dose achieved at least 30% body weight reduction.

Influenza Vaccine Dose and Dementia Outcomes

US claims data compare high- vs standard-dose formulations in patients aged 65 years or more over 3 years of follow-up