Polysaccharides-gut microbiota interaction: mechanisms regulating the hepatocellular carcinoma immune microenvironment - Takeaways - MDSpire

Polysaccharides-gut microbiota interaction: mechanisms regulating the hepatocellular carcinoma immune microenvironment

  • By

  • Wei Peng

  • Kai Xiong

  • Yuyang Zheng

  • Jiahan Zheng

  • Yuanyuan Zhong

  • Jihao Yang

  • Yuchuan Jiang

  • June 8, 2026

  • 0 min

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  • 1

    Hepatocellular carcinoma (HCC) has a poor prognosis, with only 20-30% of patients responding to immune checkpoint inhibitors.

  • 2

    Gut microbiota dysbiosis contributes to HCC progression by promoting chronic inflammation and immunosuppression through various metabolites.

  • 3

    Polysaccharides can selectively enrich beneficial gut bacteria and modulate the immune microenvironment in HCC via key signaling pathways.

  • 4

    The interaction between polysaccharides and gut microbiota may reshape the immunosuppressive tumor microenvironment in HCC.

  • 5

    Challenges in polysaccharide-based therapies for HCC include structural heterogeneity and unclear microbiota-immune relationships.

Original Source(s)

Polysaccharides-gut microbiota interaction: mechanisms regulating the hepatocellular carcinoma immune microenvironment

  • by Wei Peng, Kai Xiong, Yuyang Zheng, Jiahan Zheng, Yuanyuan Zhong, Jihao Yang, Yuchuan Jiang

  • June 8, 2026

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