Cerebrovascular thrombosis during pediatric ALL therapy: a case series highlighting temporal association with PEG-asparaginase exposure - Takeaways - MDSpire

Cerebrovascular thrombosis during pediatric ALL therapy: a case series highlighting temporal association with PEG-asparaginase exposure

  • By

  • Chen Xu

  • Jianchun Lu

  • Weihao Ling

  • Bingbing Zhang

  • Huan Xu

  • Jihong Tang

  • June 15, 2026

  • 0 min

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  • 1

    Cerebrovascular thrombosis is a rare but serious complication in children with acute lymphoblastic leukemia undergoing chemotherapy.

  • 2

    In a study of 1,138 pediatric ALL patients, six developed cerebrovascular thrombosis, indicating an incidence of 0.53%.

  • 3

    Most thrombotic events occurred 5–17 days after PEG-asparaginase administration, highlighting a critical monitoring period.

  • 4

    Elevated D-dimer levels and reduced antithrombin III activity were consistently observed at symptom onset in affected patients.

  • 5

    Therapeutic interventions, including low-molecular-weight heparin and mechanical thrombectomy, led to favorable neurological outcomes.

Original Source(s)

Cerebrovascular thrombosis during pediatric ALL therapy: a case series highlighting temporal association with PEG-asparaginase exposure

  • by Chen Xu, Jianchun Lu, Weihao Ling, Bingbing Zhang, Huan Xu, Jihong Tang

  • June 15, 2026

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