Calcium dysregulation in diabetic cardiomyopathy & heart failure with preserved ejection fraction - Takeaways - MDSpire

Calcium dysregulation in diabetic cardiomyopathy & heart failure with preserved ejection fraction

  • By

  • Anza Ali

  • Vineet M. Sharma

  • Yuriana Aguilar-Sanchez

  • June 23, 2026

  • 0 min

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  • 1

    Diabetes is a significant risk factor for cardiovascular disease, particularly heart failure with preserved ejection fraction (HFpEF).

  • 2

    Diabetic cardiomyopathy (DbCM) leads to cardiac dysfunction without significant coronary artery disease, hypertension, or valvular heart disease.

  • 3

    Impairment of calcium-handling proteins like SERCA2a and RyR2 contributes to the progression of DbCM and heart failure.

  • 4

    Current understanding of DbCM is limited, and there are no effective cures to reverse its progression or HFpEF.

  • 5

    Adeno-associated virus (AAV)-mediated gene therapies are being explored as potential treatments for diabetes-induced cardiomyopathy.

Original Source(s)

Calcium dysregulation in diabetic cardiomyopathy & heart failure with preserved ejection fraction

  • by Anza Ali, Vineet M. Sharma, Yuriana Aguilar-Sanchez

  • June 23, 2026

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