Neuronal exosomal miR-25-3p attenuates M1 microglial activation and neurotoxicity by targeting TLR4 to regulate the NF-κB signaling pathway - Takeaways - MDSpire

Neuronal exosomal miR-25-3p attenuates M1 microglial activation and neurotoxicity by targeting TLR4 to regulate the NF-κB signaling pathway

  • By

  • Guangjun Hu

  • Sarulatuya

  • Siyu Du

  • Zhile Huang

  • Xinyi Tang

  • June 3, 2026

  • 0 min

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  • 1

    Perioperative neurocognitive disorders (PND) are serious postoperative complications in the elderly, linked to neuroinflammation and M1 microglial activation.

  • 2

    Neuron-derived exosomes containing miR-25-3p can modulate microglial polarization and inhibit the TLR4/NF-κB signaling pathway.

  • 3

    Exosomal miR-25-3p directly targets TLR4, suppressing M1 microglial polarization and reducing pro-inflammatory cytokine release.

  • 4

    Inhibition of M1 microglia by miR-25-3p attenuates neuronal apoptosis and oxidative stress, mitigating neurotoxicity.

  • 5

    The study provides insights into neuron-glia communication and potential therapeutic targets for managing PND.

Original Source(s)

Neuronal exosomal miR-25-3p attenuates M1 microglial activation and neurotoxicity by targeting TLR4 to regulate the NF-κB signaling pathway

  • by Guangjun Hu, Sarulatuya, Siyu Du, Zhile Huang, Xinyi Tang

  • June 3, 2026

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