Integrative multi-omics reveals that downregulation of HLA-DPA1/DPB1 drives macrophage immune-metabolic dysregulation in pediatric asthma - Takeaways - MDSpire

Integrative multi-omics reveals that downregulation of HLA-DPA1/DPB1 drives macrophage immune-metabolic dysregulation in pediatric asthma

  • By

  • Yuchen Wen

  • Zefan Du

  • Zhiyuan Zhong

  • Qiurong Yuan

  • Liangkang Lin

  • Ran Yao

  • Jiaying He

  • Qionghui Huang

  • Liang Li

  • Cheng Ouyang

  • Junbing Huang

  • Su Liu

  • Chun Chen

  • June 3, 2026

  • 0 min

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  • 1

    HLA-DPA1 and HLA-DPB1 were identified as key genes downregulated in pediatric asthma, correlating with immune-metabolic dysregulation.

  • 2

    The study utilized bulk RNA-sequencing and machine learning algorithms to validate the significance of HLA-DPA1 and HLA-DPB1.

  • 3

    Downregulation of HLA-DPA1/DPB1 was linked to impaired antigen presentation and increased metabolic dysfunction in macrophages.

  • 4

    Single-cell RNA-seq analysis revealed HLA-DPA1/DPB1 enrichment in a macrophage subset associated with metabolic stress.

  • 5

    These findings suggest HLA-DPA1 and HLA-DPB1 as potential targets for precision therapies in pediatric asthma.

Original Source(s)

Integrative multi-omics reveals that downregulation of HLA-DPA1/DPB1 drives macrophage immune-metabolic dysregulation in pediatric asthma

  • by Yuchen Wen, Zefan Du, Zhiyuan Zhong, Qiurong Yuan, Liangkang Lin, Ran Yao, Jiaying He, Qionghui Huang, Liang Li, Cheng Ouyang, Junbing Huang, Su Liu, Chun Chen

  • June 3, 2026

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