Alanine aminotransferase elevation in hospitalized children with infectious mononucleosis: independent associations with Epstein–Barr virus DNA load, age, and sex - Takeaways - MDSpire

Alanine aminotransferase elevation in hospitalized children with infectious mononucleosis: independent associations with Epstein–Barr virus DNA load, age, and sex

  • By

  • Songlin Gan

  • Yuan Tang

  • Lianying Jiang

  • Huazhuo Mai

  • July 7, 2026

  • 0 min

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  • 1

    The study analyzed 365 hospitalized children with EBV-associated infectious mononucleosis and measured EBV DNA and ALT levels at admission.

  • 2

    Higher EBV DNA load was significantly associated with increased ALT levels, with a 38% increase for each 10-fold rise in EBV DNA.

  • 3

    Older age groups showed higher odds of ALT elevation, with adjusted odds ratios of 2.08 for ages 3-6 and 5.89 for ages ≥6 compared to those <3.

  • 4

    Male sex was linked to lower odds of ALT elevation, with an adjusted odds ratio of 0.29.

  • 5

    The association between EBV DNA load and ALT elevation was consistent across different age groups and remained stable in sensitivity analyses.

Original Source(s)

Alanine aminotransferase elevation in hospitalized children with infectious mononucleosis: independent associations with Epstein–Barr virus DNA load, age, and sex

  • by Songlin Gan, Yuan Tang, Lianying Jiang, Huazhuo Mai

  • July 7, 2026

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