A preliminary study on the combined assessment of 25-hydroxyvitamin D and thyroid function for predicting diabetic foot risk and amputation in type 2 diabetes - Takeaways - MDSpire

A preliminary study on the combined assessment of 25-hydroxyvitamin D and thyroid function for predicting diabetic foot risk and amputation in type 2 diabetes

  • By

  • Dan Xiong

  • Yuanfang Jiang

  • Zhengxia Yu

  • Yaqin Zhong

  • Ke Peng

  • Xianglong Xia

  • Youqi Zhang

  • Lijun Liu

  • Weixia Peng

  • June 15, 2026

  • 0 min

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  • 1

    Patients with diabetic foot had significantly lower serum 25-hydroxyvitamin D and FT3 levels compared to those with uncomplicated type 2 diabetes.

  • 2

    The deficiency of 25-hydroxyvitamin D (<20 ng/mL) was associated with a higher risk of diabetic foot, while FT3 was identified as an independent protective factor.

  • 3

    ROC analysis indicated that the combined predictive probability of 25-hydroxyvitamin D and FT3 improved the prediction of diabetic foot compared to either marker alone.

  • 4

    In diabetic foot patients, the prevalence of euthyroid sick syndrome was higher, and those with ESS had lower 25-hydroxyvitamin D levels than the euthyroid group.

  • 5

    The amputation rate was significantly higher in the ESS group compared to the euthyroid group, with notable differences in CRP and TSH levels among amputation groups.

Original Source(s)

A preliminary study on the combined assessment of 25-hydroxyvitamin D and thyroid function for predicting diabetic foot risk and amputation in type 2 diabetes

  • by Dan Xiong, Yuanfang Jiang, Zhengxia Yu, Yaqin Zhong, Ke Peng, Xianglong Xia, Youqi Zhang, Lijun Liu, Weixia Peng

  • June 15, 2026

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