Longitudinal Changes in Cognition and Brain Imaging in Persons With Human Immunodeficiency Virus - Takeaways - MDSpire

Longitudinal Changes in Cognition and Brain Imaging in Persons With Human Immunodeficiency Virus

  • By

  • James Kennedy

  • Sarah A Cooley

  • June Roman Fox

  • Kalen J Petersen

  • Elizabeth Westerhaus

  • Pat Reid

  • Linet Lopez

  • Beau M Ances

  • January 16, 2026

  • 0 min

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  • 1

    The study analyzed cognitive and brain volume changes in individuals with HIV and without HIV across different viral load statuses.

  • 2

    PWH with detectable viral loads exhibited a steeper cognitive decline compared to those with undetectable viral loads and individuals without HIV.

  • 3

    Both PWH groups had smaller regional brain volumes than PWOH, but the rate of volume loss with age was similar across all groups.

  • 4

    Achieving viral suppression in PWH appears to prevent accelerated cognitive decline and brain volume loss compared to PWOH.

  • 5

    The findings emphasize the importance of managing viral load in aging PWH to mitigate cognitive decline risks.

Original Source(s)

Longitudinal Changes in Cognition and Brain Imaging in Persons With Human Immunodeficiency Virus

  • by James Kennedy, Sarah A Cooley, June Roman Fox, Kalen J Petersen, Elizabeth Westerhaus, Pat Reid, Linet Lopez, Beau M Ances

  • January 16, 2026

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