Guanxinjing Enhances Coronary Microvascular Function in Myocardial Ischemia-Reperfusion Injury by Reducing Inflammation and Improving Endothelial Activity

1

Guanxinjing compound (GXJC) is used clinically for coronary heart disease and may improve coronary microvascular function.
2

GXJC treatment reduced myocardial infarct size and cardiomyocyte apoptosis in a mouse model of myocardial ischemia-reperfusion injury.
3

The study identified 256 bioactive compounds in GXJC and highlighted the TNF signaling pathway as a key mechanism.
4

GXJC suppressed inflammation by inhibiting pro-inflammatory factors like IL-6 and IL-1β, improving endothelial function.
5

The findings support the potential of GXJC as a therapeutic agent for myocardial ischemia-reperfusion injury.

Frontiers In Immunology

by Yaoting Wang, Lan Li, Liang Jin, Shikai Zhan, Hai Ren, Jiao Zhao, Qiuru Wang, Yiqiong Wang, Shudong Lin, Jiaxing Xin, Yao Dai, Yifan Zhou, Ting Zhang, Qian Liu, Yunyun Lu, Yiqi Zhu, Jiangyue Wu, Jiayan Lin, Shujing Zhang, Ling Zhang
July 17, 2026

1