Protein lactylation in myocardial ischemia-reperfusion injury: mechanisms and therapeutic potential

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Myocardial ischemia-reperfusion injury (MIRI) is a significant complication in cardiovascular therapy, often exacerbated by reperfusion itself.
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Protein lactylation (Kla) is a post-translational modification linked to lactate metabolism, influencing cardiomyocyte responses to ischemic stress.
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Kla affects key biological processes such as apoptosis, inflammation, and cardiac remodeling, highlighting its role in MIRI pathogenesis.
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Current literature lacks a comprehensive review on the relationship between Kla and MIRI, indicating a gap in understanding its mechanisms.
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Future research should focus on elucidating Kla's role in MIRI to inform the development of novel therapeutic strategies.

Frontiers In Cardiovascular Medicine

by Hang Zhan, Die Li, Jiayao He, Yuzhuang Hu, Wei Jiang, Jiayu Zhang, Wei Chen, Weize Xu
July 16, 2026

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