Opinion: a call for safe therapeutic and gastric interventions for adolescents and young adults with obesity and transplant-indicated leukemia - Takeaways - MDSpire

Opinion: a call for safe therapeutic and gastric interventions for adolescents and young adults with obesity and transplant-indicated leukemia

  • By

  • Miriam B. Garcia

  • Paul Perales

  • David Santos

  • Ching-Wei D. Tzeng

  • Branko Cuglievan

  • Irtiza N. Sheikh

  • May 7, 2026

  • 0 min

Share

  • 1

    Obesity in adolescents and young adults with leukemia increases treatment complications and negatively impacts survival outcomes.

  • 2

    AYA patients with obesity undergoing HSCT face higher rates of non-relapse mortality and poorer overall survival compared to those with normal weight.

  • 3

    Current literature lacks comprehensive studies on obesity management in pediatric and AYA leukemia patients requiring HSCT.

  • 4

    Practice changes at MD Anderson include normalizing chemotherapy dosing to ideal body weight to mitigate obesity-related risks.

  • 5

    The Hematopoietic Cell Transplantation-specific Comorbidity Index is utilized to assess obesity-related risks in HSCT candidates.

Original Source(s)

Opinion: a call for safe therapeutic and gastric interventions for adolescents and young adults with obesity and transplant-indicated leukemia

  • by Miriam B. Garcia, Paul Perales, David Santos, Ching-Wei D. Tzeng, Branko Cuglievan, Irtiza N. Sheikh

  • May 7, 2026

Related Content

Granulocyte transfusions in haematopoietic cell transplants and leukaemia: the phoenix or beating a dead horse?

Meet the Team: Shernan Holtan, MD

The newest member of the cellular therapy research team and Chief of the Bone Marrow and Transplantation Service at Roswell Park Comprehensive Cancer Center is eager to continue advancing the field.

  • February 23, 2024

  • 2 min
Prevalence and Contributing Factors of Hypothyroidism in Hematological Malignancy Patients Compared to Healthy Individuals: A Systematic Review and Meta-Analysis