The Influence of a Roux-en-Y Gastric Bypass on Plasma Concentrations of Antidepressants - Takeaways - MDSpire

The Influence of a Roux-en-Y Gastric Bypass on Plasma Concentrations of Antidepressants

  • By

  • Paul Garin

  • Lucie Favre

  • Nathalie Vionnet

  • Johanna Frantz

  • Chin B. Eap

  • Frederik Vandenberghe

  • March 22, 2023

  • 0 min

Share

  • 1

    Obesity and depression have a reciprocal relationship, increasing the prevalence of antidepressant prescriptions in obese patients.

  • 2

    Roux-en-Y gastric bypass (RYGB) surgery alters drug pharmacokinetics, potentially affecting the absorption of antidepressants.

  • 3

    Studies indicate a significant decrease in plasma concentrations of various antidepressants post-RYGB, impacting their efficacy.

  • 4

    Longitudinal data show that depressive symptoms may increase after two years post-bariatric surgery, despite initial improvements.

  • 5

    A multidisciplinary approach is recommended for managing antidepressant therapy in patients undergoing RYGB to ensure optimal treatment.

Original Source(s)

The Influence of a Roux-en-Y Gastric Bypass on Plasma Concentrations of Antidepressants

  • by Paul Garin, Lucie Favre, Nathalie Vionnet, Johanna Frantz, Chin B. Eap, Frederik Vandenberghe

  • March 22, 2023

Related Content

Correction to: One Anastomosis Gastric Bypass Versus Single Anastomosis Sleeve Jejunal Bypass: Does Duodenal Exclusion Matter?

Impaired Iron-Copper Metabolic Axis in Human Intestinal Mucosa After Roux-en-Y Gastric Bypass: A Prospective Transcriptomic Study Using Double-Balloon Enteroscopy

Postop Pain Differs by Vitamin D Status

Patients with preoperative vitamin D deficiency had higher postoperative pain scores and opioid use after mastectomy, including more than triple the odds of moderate to severe pain within 24 hours of surgery.