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Addressing the Complexity of Septic Microvascular Dysfunction: Shear Stress and Beyond

  • By

  • Ivor Popovich

  • July 20, 2026

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  • 1

    Septic microvascular dysfunction involves leucocyte adhesion, coagulation, and endothelial shedding.

  • 2

    Shear stress influences adhesion and thrombosis, highlighting its role in septic microvascular dysfunction.

  • 3

    Biological and physical models complement each other in understanding complex processes like sepsis.

  • 4

    The shear model remains experimentally untested, and its relevance to sepsis requires further investigation.

  • 5

    The dominant theory of cytokine storm in sepsis has not improved patient outcomes despite extensive research.

Original Source(s)

In reply to; beyond shear stress: septic microvascular failure remains a multifactorial phenomenon

  • by Ivor Popovich

  • July 20, 2026

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