In reply to; beyond shear stress: septic microvascular failure remains a multifactorial phenomenon - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

Addressing the Complexity of Septic Microvascular Dysfunction: Shear Stress and Beyond

  • By

  • Ivor Popovich

  • July 20, 2026

Share

  • 1

    Septic microvascular dysfunction involves leucocyte adhesion, coagulation, and endothelial shedding.

  • 2

    Shear stress influences adhesion and thrombosis, highlighting its role in septic microvascular dysfunction.

  • 3

    Biological and physical models complement each other in understanding complex processes like sepsis.

  • 4

    The shear model remains experimentally untested, and its relevance to sepsis requires further investigation.

  • 5

    The dominant theory of cytokine storm in sepsis has not improved patient outcomes despite extensive research.

Original Source(s)

In reply to; beyond shear stress: septic microvascular failure remains a multifactorial phenomenon

  • by Ivor Popovich

  • July 20, 2026

Related Content

Online explainable machine learning prediction of sepsis in hemorrhagic stroke: Development and multicenter external validation

Familial Transmission of Invasive Group A Streptococcus: A Case Series

  • July 7, 2026

Association between clinical characteristics within 6 h of ICU admission and 30-day mortality risk in immunocompromised sepsis patients: development and validation of a machine learning model based on the MIMIC-IV database