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1
The liver-brain axis (LBA) is a bidirectional communication network integrating neural, humoral, and immune pathways.
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2
LBA dysfunction is a core driver of obesity, diabetes, cardiovascular diseases, and psychiatric disorders like anxiety and depression.
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3
The liver actively modulates peripheral neuroimmune responses, challenging the view of it as a passive metabolic organ.
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4
Emerging therapeutic strategies targeting the LBA show potential for managing metabolic dysfunction-associated liver diseases and related psychiatric conditions.
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5
The LBA facilitates critical inter-organ communication, influencing both metabolic status and neurocognitive functions.
