Editorial: Cardiovascular risks in cardiovascular-kidney-metabolic syndrome: mechanisms and therapies - Takeaways - MDSpire

Editorial: Cardiovascular risks in cardiovascular-kidney-metabolic syndrome: mechanisms and therapies

  • By

  • Ruoyu Zhou

  • Bo Zhang

  • Weihao Wang

  • Jiyuan Piao

  • Wanlu Ma

  • May 1, 2026

  • 0 min

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  • 1

    The cardiovascular-kidney-metabolic (CKM) syndrome links metabolic disorders, kidney disease, and heart disease, exacerbating each condition's severity.

  • 2

    Composite metabolic-inflammatory biomarkers, like the triglyceride-glucose index, improve risk stratification for cardiovascular and renal outcomes.

  • 3

    CKM syndrome mechanisms include insulin resistance, chronic inflammation, and endothelial dysfunction, creating a cycle of worsening health.

  • 4

    Therapeutic strategies for CKM syndrome emphasize tailored interventions that align drug mechanisms with individual pathophysiological factors.

  • 5

    SGLT2 inhibitors show benefits beyond glycemic control, impacting uric acid levels and providing cardiovascular and renal protection.

Original Source(s)

Editorial: Cardiovascular risks in cardiovascular-kidney-metabolic syndrome: mechanisms and therapies

  • by Ruoyu Zhou, Bo Zhang, Weihao Wang, Jiyuan Piao, Wanlu Ma

  • May 1, 2026

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