LncRNA EGFR-AS1 Modulates Ferroptosis to Decrease Cervical Cancer Radiosensitivity via the m6A/IGF2BP3/APAF1 Pathway

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Cervical cancer is a prevalent malignancy with increasing incidence among young women, leading to significant health risks.
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Approximately 50% of advanced cervical cancer patients are resistant to radiotherapy, resulting in poor prognosis and tumor recurrence.
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Ferroptosis is a distinct form of programmed cell death that may enhance the effectiveness of radiotherapy in cervical cancer.
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LncRNAs play a crucial role in modulating the sensitivity of cervical cancer cells to radiotherapy and ferroptosis.
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The study aims to investigate the lncRNA EGFR-AS1's role in ferroptosis and its impact on cervical cancer radiosensitivity.

Bmc Cancer

by Xianglong Chen, Jingyu Li, Yujie Sun, Zhaoyu Ye, Man Long, Junguo Bu, Zirong Fan, Zhaojing Jiang
March 5, 2026

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