Phosphaturic mesenchymal tumor in the temporalis muscle causing tumor-induced osteomalacia: a case report and literature review - Takeaways - MDSpire

Phosphaturic mesenchymal tumor in the temporalis muscle causing tumor-induced osteomalacia: a case report and literature review

  • By

  • Bo Gao

  • Chao Wang

  • Xiaoming Xu

  • Xiuxiu Lai

  • Xiaohong Xu

  • May 14, 2026

  • 0 min

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  • 1

    Tumor-induced osteomalacia (TIO) is a rare syndrome caused by phosphaturic mesenchymal tumors (PMTs), leading to renal phosphate wasting and hypophosphatemia.

  • 2

    PMTs are often difficult to localize due to their small size and non-specific symptoms, resulting in an average diagnostic delay of 4.8 years.

  • 3

    A 54-year-old man with progressive polyarthralgia and hypophosphatemia was diagnosed with a PMT in the left temporalis muscle using 68Ga-DOTA-TATE PET/CT.

  • 4

    Histopathological examination confirmed the PMT diagnosis, and the tumor was completely resected, with no recurrence observed at 6 months post-surgery.

  • 5

    Clinicians should consider PMTs in patients with unexplained hypophosphatemia and utilize functional imaging like 68Ga-DOTA-TATE PET/CT for early detection.

Original Source(s)

Phosphaturic mesenchymal tumor in the temporalis muscle causing tumor-induced osteomalacia: a case report and literature review

  • by Bo Gao, Chao Wang, Xiaoming Xu, Xiuxiu Lai, Xiaohong Xu

  • May 14, 2026

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