Sonazoid-enhanced ultrasound for preoperative localization and characterization of sentinel lymph nodes in patients with cutaneous melanoma

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Cutaneous malignant melanoma is a prevalent skin cancer, with sentinel lymph nodes being critical for staging and treatment planning.
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Sentinel lymph node biopsy is the standard procedure for clinically node-negative melanoma patients, providing essential prognostic information.
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Traditional SLN localization methods, like lymphoscintigraphy, have limitations including allergic reactions and radiation risks.
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Sonazoid, a novel ultrasound contrast agent, enhances SLN visualization and offers advantages over traditional tracers in melanoma staging.
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This study evaluates the feasibility and safety of Sonazoid for SLN identification, aiming to improve preoperative staging in melanoma patients.

European Radiology

by Binbin Jiang, Liqi Sun, Lu Si, Jiayong Liu, Chuanliang Cui, Kun Yan, Shanshan Yin
May 25, 2026

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