Head and Neck Squamous Cell Carcinoma Associated with Human Papillomavirus (HPV) in a Diverse Developing Nation - Takeaways - MDSpire

Head and Neck Squamous Cell Carcinoma Associated with Human Papillomavirus (HPV) in a Diverse Developing Nation

  • By

  • Hans Prakash Sathasivam

  • Rohaizam Japar

  • Zanariah Alias

  • Zahirrudin Zakaria

  • Hasmah Hashim

  • Shashi Gopalan Marimuthu

  • Noraida Khalid

  • Pappathy Vairavan

  • Angeline Madatang

  • Doh Jeing Yong

  • Avatar Singh Mohan Singh

  • Abd Razak Ahmad

  • January 30, 2026

  • 0 min

Share

  • 1

    HPV is linked to approximately 42,000 cases of head and neck cancers globally, with a significant prevalence in oropharyngeal squamous cell carcinoma.

  • 2

    Current data on HPV-driven head and neck squamous cell carcinoma in Malaysia is limited, highlighting a gap in understanding its epidemiology.

  • 3

    p16INK4a immunohistochemistry is commonly used to assess HPV status, but it is a surrogate marker and not a direct detection method.

  • 4

    Combining p16INK4a IHC with molecular tests for HPV DNA or E6/E7 mRNA improves accuracy in determining HPV-driven tumors.

  • 5

    This study aims to estimate the prevalence of HPV-driven HNSCC in Malaysia using RNA in situ hybridization, considered the clinical gold standard.

Original Source(s)

Head and Neck Squamous Cell Carcinoma Associated with Human Papillomavirus (HPV) in a Diverse Developing Nation

  • by Hans Prakash Sathasivam, Rohaizam Japar, Zanariah Alias, Zahirrudin Zakaria, Hasmah Hashim, Shashi Gopalan Marimuthu, Noraida Khalid, Pappathy Vairavan, Angeline Madatang, Doh Jeing Yong, Avatar Singh Mohan Singh, Abd Razak Ahmad

  • January 30, 2026

Related Content

Artificial intelligence for optimization of immunotherapy: current applications and transformative potential

Outcomes of critically ill pediatric patients after haploidentical stem cell transplantation

Case Report: First description of an intracranial “NET” in ROHHAD syndrome; time to rename to the ROHHAD-NeCT syndrome?