Microbiota metabolite butyrate alleviates intestinal inflammation associated with enhanced autophagy-related signaling in DSS-induced colitis - Takeaways - MDSpire

Microbiota metabolite butyrate alleviates intestinal inflammation associated with enhanced autophagy-related signaling in DSS-induced colitis

  • By

  • Qingyi Mao

  • Beibei Lin

  • Wenluo Zhang

  • Yu Zhang

  • Yue Lei

  • Zhou Zhang

  • Mengque Xu

  • June 17, 2026

  • 0 min

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  • 1

    Butyrate levels are significantly lower in IBD patients compared to healthy controls, indicating a potential link to intestinal inflammation.

  • 2

    Oral sodium butyrate treatment in mice improved gut microbiota composition and restored intestinal barrier function during DSS-induced colitis.

  • 3

    Enhanced autophagy signaling was observed in the intestines of butyrate-treated mice, indicated by increased ATG16L1 and LC3-II protein levels.

  • 4

    Inhibition of autophagy with 3-methyladenine diminished the protective effects of butyrate against colonic injury in mice.

  • 5

    The study suggests a gut microbiota-butyric acid-autophagy axis that may be targeted for therapeutic strategies in inflammatory bowel disease.

Original Source(s)

Microbiota metabolite butyrate alleviates intestinal inflammation associated with enhanced autophagy-related signaling in DSS-induced colitis

  • by Qingyi Mao, Beibei Lin, Wenluo Zhang, Yu Zhang, Yue Lei, Zhou Zhang, Mengque Xu

  • June 17, 2026

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