Soluble CD147 in Plasma During Sepsis: Correlation with Disease Severity and Prognostic Implications - Takeaways - MDSpire

Soluble CD147 in Plasma During Sepsis: Correlation with Disease Severity and Prognostic Implications

  • By

  • Jiaqi Chen

  • Hui Zhang

  • Yini Sun

  • Yukun Chang

  • Sheng Tu

  • Yang Xiao

  • Xiaowen Yu

  • Pan Wang

  • Zining Zhang

  • Yajing Fu

  • Qinghai Hu

  • Hong Shang

  • Yongjun Jiang

  • April 28, 2026

  • 0 min

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  • 1

    Plasma levels of soluble CD147 (sCD147) are significantly elevated in septic patients compared to non-septic controls and healthy donors.

  • 2

    sCD147 levels correlate positively with disease severity indicators, including SOFA scores and markers of organ injury.

  • 3

    Higher sCD147 levels at ICU admission are associated with increased mortality risk in septic patients.

  • 4

    sCD147 serves as an independent predictor of mortality, outperforming SOFA scores in predictive accuracy.

  • 5

    The findings suggest sCD147 is a promising biomarker for sepsis severity and prognosis, warranting further research.

Original Source(s)

Soluble CD147 in Plasma During Sepsis: Correlation with Disease Severity and Prognostic Implications

  • by Jiaqi Chen, Hui Zhang, Yini Sun, Yukun Chang, Sheng Tu, Yang Xiao, Xiaowen Yu, Pan Wang, Zining Zhang, Yajing Fu, Qinghai Hu, Hong Shang, Yongjun Jiang

  • April 28, 2026

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