Clinical Case Study: Autoimmune Hemolytic Anemia and Hepatitis Triggered by EBV-Related Infectious Mononucleosis - Takeaways - MDSpire

Clinical Case Study: Autoimmune Hemolytic Anemia and Hepatitis Triggered by EBV-Related Infectious Mononucleosis

  • By

  • Akram Alnounou

  • Henry Zou

  • Madison C. Laird

  • Sophie Numbers

  • Christopher Visak

  • Sage Bilsland

  • Neil Hughes

  • Eric Martin Sieloff

  • April 17, 2026

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  • 1

    EBV can cause rare complications like autoimmune hemolytic anemia and hepatitis, even in previously healthy individuals.

  • 2

    An 18-year-old female presented with jaundice, red urine, and arthralgia, leading to a diagnosis of EBV-related autoimmune hemolytic anemia.

  • 3

    Laboratory findings included direct hyperbilirubinemia, elevated transaminases, and a positive direct antiglobulin test for IgG.

  • 4

    The patient was managed conservatively with hydration and limited steroid use, showing clinical improvement without hepatic failure.

  • 5

    This case highlights the need for awareness of atypical EBV presentations and careful management of overlapping autoimmune complications.

Original Source(s)

Clinical Case Study: Autoimmune Hemolytic Anemia and Hepatitis Triggered by EBV-Related Infectious Mononucleosis

  • by Akram Alnounou, Henry Zou, Madison C. Laird, Sophie Numbers, Christopher Visak, Sage Bilsland, Neil Hughes, Eric Martin Sieloff

  • April 17, 2026

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