Detailed investigation of B cell populations following vaccination and infection with severe acute respiratory syndrome coronavirus-2 during pregnancy - Takeaways - MDSpire

Detailed investigation of B cell populations following vaccination and infection with severe acute respiratory syndrome coronavirus-2 during pregnancy

  • By

  • Laura Scholz

  • Nils Hoymann

  • Suzan Alboradi

  • Valeriia Grabar

  • Gina Marie Uehre

  • George Toth

  • József Mészáros

  • Paolo Gennari

  • Svetlana Tchaikovski

  • Atanas Ignatov

  • Mandy Busse

  • June 16, 2026

  • 0 min

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  • 1

    Pregnancy alters B cell populations, impacting the balance between B effector and B regulatory cells.

  • 2

    SARS-CoV-2 vaccination and infection significantly change the frequency of plasma blasts, plasma cells, and B memory cells.

  • 3

    Infected women showed increased IL-10+ B cells and decreased IL-6+ B cells compared to vaccinated women.

  • 4

    Vaccination enhanced the expression of PD-1, FasL, and CD86 on B cells, while infection induced CD40 expression.

  • 5

    The study highlights the need for further research on maternal SARS-CoV-2 immunity's long-term effects on mothers and offspring.

Original Source(s)

Detailed investigation of B cell populations following vaccination and infection with severe acute respiratory syndrome coronavirus-2 during pregnancy

  • by Laura Scholz, Nils Hoymann, Suzan Alboradi, Valeriia Grabar, Gina Marie Uehre, George Toth, József Mészáros, Paolo Gennari, Svetlana Tchaikovski, Atanas Ignatov, Mandy Busse

  • June 16, 2026

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