Glycemic variability may signal retinal changes

Greater glucose fluctuations but not HbA1c were associated with neuroretinal alterations over 3 years in pediatric patients with type 1 diabetes.

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Glycemic variability may indicate early neuroretinal changes in pediatric patients with type 1 diabetes without microvascular complications.
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A 3-year study with 25 type 1 diabetes patients and 18 controls used OCT to measure retinal layer thickness.
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Thinning of the inner ganglion cell layer and outer plexiform layer was statistically significant among patients with type 1 diabetes.
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Greater glycemic variability correlated with thinner retinal layers, while greater time in range was linked to thicker layers.
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The study's findings suggest a need for further research to explore neuroretinal damage as a potential marker for diabetic neuropathy.

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